Stationary distribution of the linkage disequilibrium coefficient r2
نویسندگان
چکیده
منابع مشابه
Analytic computation of the expectation of the linkage disequilibrium coefficient r2.
The squared correlation coefficient r(2) (sometimes denoted Delta(2)) is a measure of linkage disequilibrium that is widely used, but computing its expectation E[r(2)] in the population has remained an intriguing open problem. The expectation E[r(2)] is often approximated by the standard linkage deviation sigma(d)(2), which is a ratio of two expectations amenable to analytic computation. In thi...
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Statistics for linkage disequilibrium (LD), the non-random association of alleles at two loci, depend on the frequencies of the alleles at the loci under consideration. Here, we examine the r(2) measure of LD and its mathematical relationship to allele frequencies, quantifying the constraints on its maximum value. Assuming independent uniform distributions for the allele frequencies of two bial...
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ژورنال
عنوان ژورنال: Theoretical Population Biology
سال: 2019
ISSN: 0040-5809
DOI: 10.1016/j.tpb.2019.05.002